Flow-Injection Amperometric Determination of Tacrine based on Ion Transfer across a Water–Plasticized Polymeric Membrane Interface
نویسندگان
چکیده
A flow-injection pulse amperometric method for determining tacrine, based on ion transfer across a plasticized poly(vinyl chloride) (PVC) membrane, was developed. A four-electrode potentiostat with ohmic drop compensation was used, while a flow-through cell incorporated the four electrodes and the membrane, which contained tetrabutylammonium tetraphenylborate. The influence of the applied potential and of the flow-injection variables on the determination of tacrine was studied. In the selected conditions, a linear relationship between peak height and tacrine concentration was found up to 4x10M tacrine. The detection limit was 1x10M. Good repeatability was obtained. Some common ions and pharmaceutical excipients did not interfere.
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